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Henderson is a small rural community in southern Caroline County near the Choptank River, with a population of a few hundred residents. Like much of interior Caroline County, Henderson's economy revolves around agriculture — grain farming, poultry production, and small farm operations. The community supports a volunteer fire company and a handful of local businesses serving the surrounding farming population. Easy access to U.S. Route 50 connects residents to the larger commercial hubs of Denton and Easton.